Hiroki Kakuta Selected Research

1- (3,5,5,8,8- pentamethyl- 5,6,7,8- tetrahydro- 2- naphthyl)- 1H- benzotriazole- 5- carboxylic acid

1/2019	A partial agonist for retinoid X receptor mitigates experimental colitis.
1/2019	Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα).
1/2017	Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof.
3/2013	Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.
5/2012	RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.

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Hiroki Kakuta Research Topics

Disease

10	Type 2 Diabetes Mellitus (MODY) 10/2019 - 09/2010
7	Neoplasms (Cancer) 01/2022 - 03/2008
4	Inflammation (Inflammations) 01/2019 - 07/2008
4	Breast Neoplasms (Breast Cancer) 08/2014 - 03/2008
3	Hypothyroidism 01/2017 - 01/2011
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2011 - 02/2009
3	Hyperlipidemias (Hyperlipidemia) 01/2011 - 09/2010
3	Lung Neoplasms (Lung Cancer) 02/2009 - 03/2008
2	Colitis 01/2021 - 01/2019
2	Hepatomegaly 01/2019 - 01/2012
2	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 01/2019 - 04/2014
2	Central Nervous System Diseases (CNS Diseases) 01/2019 - 01/2017
2	Hypersensitivity (Allergy) 08/2018 - 02/2009
2	Insulin Resistance 05/2012 - 01/2011
2	Malaria 06/2008 - 10/2007
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Carcinoma (Carcinomatosis) 01/2022
1	Neuroblastoma 01/2022
1	Parkinson Disease (Parkinson's Disease) 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Disease Susceptibility (Diathesis) 01/2020
1	Pulmonary Emphysema 01/2019
1	Emphysema 01/2019
1	Hypertriglyceridemia 01/2019
1	Ulcerative Colitis 01/2019
1	Crohn Disease (Crohn's Disease) 01/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019
1	Prostatic Neoplasms (Prostate Cancer) 12/2018
1	Asthma (Bronchial Asthma) 01/2017
1	Edema (Dropsy) 09/2014
1	Pain (Aches) 03/2011
1	Retinal Neovascularization 02/2011
1	Macular Degeneration (Age-Related Maculopathy) 02/2011
1	Blindness (Hysterical Blindness) 02/2011
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 02/2011
1	Diabetic Retinopathy (Retinopathy, Diabetic) 02/2011
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2011
1	Allergic Rhinitis 06/2010
1	Stomach Ulcer (Gastric Ulcer) 12/2008

Drug/Important Bio-Agent (IBA)

22	Retinoid X Receptors (Retinoid X Receptor)IBA 01/2022 - 03/2008
5	1- (3,5,5,8,8- pentamethyl- 5,6,7,8- tetrahydro- 2- naphthyl)- 1H- benzotriazole- 5- carboxylic acidIBA 01/2019 - 05/2012
4	Bexarotene (LGD1069)FDA Link 01/2019 - 04/2014
4	Triglycerides (Triacylglycerol)IBA 01/2017 - 01/2011
4	Glucose (Dextrose)FDA LinkGeneric 01/2012 - 09/2010
3	Paclitaxel (Taxol)FDA LinkGeneric 02/2009 - 03/2008
3	Tamoxifen FDA LinkGeneric 02/2009 - 03/2008
2	Biological ProductsIBA 01/2022 - 08/2018
2	LigandsIBA 10/2019 - 02/2009
2	Carboxylic AcidsIBA 01/2019 - 01/2017
2	benzotriazoleIBA 01/2019 - 01/2017
2	ThiazolidinedionesIBA 01/2017 - 01/2011
2	Therapeutic UsesIBA 01/2017 - 05/2012
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 03/2011 - 10/2004
2	alkoxyl radicalIBA 01/2011 - 12/2010
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 09/2010 - 09/2010
2	Liver X ReceptorsIBA 09/2010 - 09/2010
1	7-dehydrocholesterolIBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2022
1	AcidsIBA 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2020
1	Chemotactic FactorsIBA 01/2019
1	Pancreatic Elastase (Elastase)IBA 01/2019
1	Interleukin-17 (Interleukin 17)IBA 01/2019
1	SmokeIBA 01/2019
1	InterferonsIBA 01/2019
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2019
1	Dextrans (Dextran)FDA Link 01/2019
1	Docosahexaenoic AcidsIBA 01/2019
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2019
1	Hormones (Hormone)IBA 12/2018
1	Testosterone (Sustanon)FDA Link 12/2018
1	enzalutamideIBA 12/2018
1	Androgen Receptors (Androgen Receptor)IBA 12/2018
1	Benzoic Acid (Potassium Benzoate)FDA Link 01/2017
1	OvalbuminIBA 01/2017
1	fluorescent protein 583IBA 01/2016
1	CarrageenanIBA 09/2014
1	Niacin (Nicotinic Acid)FDA LinkGeneric 09/2014
1	Pioglitazone (Actos)FDA Link 09/2014
1	Dexamethasone (Maxidex)FDA LinkGeneric 09/2014
1	Thalidomide (Thalomid)FDA Link 08/2014
1	Blood Glucose (Blood Sugar)IBA 01/2012
1	2,4-thiazolidinedione (thiazolidinedione)IBA 02/2011
1	Retinaldehyde (Retinal)IBA 02/2011
1	Oxygen (Dioxygen)IBA 02/2011
1	Metformin (Glucophage)FDA LinkGeneric 01/2011
1	Insulin (Novolin)FDA Link 01/2011
1	LipidsIBA 09/2010
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 09/2010
1	PPAR gammaIBA 06/2010
1	Mesalamine (Mesalazine)FDA LinkGeneric 06/2010
1	Cyclooxygenase 1IBA 12/2008
1	Analgesics (Analgesic Drugs)IBA 12/2008
1	Small Interfering RNA (siRNA)IBA 07/2008
1	Cyclin D1IBA 07/2008

Therapy/Procedure

3	Therapeutics 05/2020 - 01/2019
1	Transplantation 01/2019
1	Castration 12/2018